Endocrine Abstracts

Miscarriage is a very common occurrence in humans, in which blastocyst implantation failure in naturally-occurring and assisted human reproduction occurs in up to 2/3 of all cases. Calcium (Ca2+) has been showed to involve in many cellular signal transduction pathways as well as regulation of cell adhesion, which is necessary for the physiology process of endometrial epithelial cell transformation and stromal cell decidualization during embryo implantation. Previous...

Introduction: Calbindin-D9k is a 9 kDa polypeptide expressed in the mammalian intestine, uterus, and pituitary gland. Calbindin-D9k increase Ca2+ absorption by buffering intracellular Ca2+. The intracellular concentration of calcium is regulated by calcium related proteins such as calbindin-D9k, TRPV1 and PMCA1. The regulatory effect of steroid hormones and glucocorticoids on calbindin-D9k, TRPV1 and PMCA1 expre...

Endocrine-disrupting chemicals (EDCs) are structures similar to steroids hormones which can interfere with hormone synthesis and normal physiological functions of male and female reproductive organs. EDCs tend to bind to steroid hormone receptors. Sex steroid hormones influence calcium signaling of the cardiac muscle in early embryo-development. Progesterone (P4) has been reported to affect both blood pressure and other aspects of the cardiovascular system. To confirm the affe...